You may need to go to the hospital for treatment. have happened in people who take Prolia. Call your doctor for medical advice about side effects. You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. You should always consult your doctor or another healthcare professional before taking any medication. These side effects may be temporary, lasting a few days or weeks. Be sure to read this information carefully each time. It is advisable to take 2 capsules in the morning with food and 1 in the evening also with food. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Do any of yall know? You should also take calcium and vitamin D supplements while being Common These are serious. Fatigue (low energy) and nausea werent specifically reported as side effects in clinical trials of Prolia. Although its rare, your doctor may give you the option to self-inject Prolia at home. In this article well discuss the uses, side effects, safety precautions, and other important information about Prolia. Breastfeeding. You can also visit the Prolia manufacturers website to see if they have support options. Call your doctor or health care professional if you are unable to keep an appointment. Another common osteoporosis medication is denosumab (Prolia, Xgeva). Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture It may not cover all possible information. Prolia is also available in a biosimilar form. Treating any mouth or dental problems early is the best way to help prevent serious dental complications. If you have a low calcium level, you should not take Prolia. According to the American Dental Association, your risk of this problem may increase if you receive denosumab (the active drug in Prolia) for longer than 2 years. Also, its important to brush and floss your teeth regularly while youre using Prolia. Dietary calcium is considered safe, but too much calcium in the form of supplements might have some health risks. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). A healthcare provider will give you this injection in a hospital or clinic. A biologic drug is made from parts of living organisms. Keep out of the reach of children and pets. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Having a tooth extraction while youre using Prolia may increase your risk for these side effects. With bone loss, your body loses old bone tissue faster than it makes new bone tissue. Side effects that you should report to your doctor or health care professional as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): This list may not describe all possible side effects. Prolia may cause serious side effects. Prolia can also cause bones to not form correctly and reduced growth in a fetus. Some people have developed unusual fractures in their thigh bone. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.) The conditions and factors to consider include: Upcoming dental procedures. Constipation was also reported as a side effect in females using Prolia for osteoporosis. They will also explain how much youll be given and how often. Follow your doctor's instructions about any restrictions on food, beverages, or activity. It is not safe to receive Prolia during pregnancy. Our website services, content, and products are for informational purposes only. In certain cases, Prolia may have contraindications (not be recommended) for you due to a higher risk for side effects. Terms of Use. Protect from light and do not freeze. WebDrug interactions are reported among people who take Prolia and Calcium. What do I need to be aware of if I need a tooth extraction while Im using Prolia? The drug could cause your calcium level to drop too low. If youre concerned about unexplained weight gain while using Prolia, talk with your doctor. Youll likely have questions about your condition and treatment choices. Because Prolia can also cause low blood calcium, your risk may increase if you receive Prolia. Usually, but it depends. Although both drugs are approved to treat similar conditions, they work in different ways. Youll receive Prolia from a healthcare professional as an injection under the skin in one of the following areas: Prolia contains the active drug denosumab, which is a biologic medication. The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. Before you start Prolia treatment, talk with your doctor about how long Prolias side effects may last. Now i am worried that i've been taking K2 which also takes calcium from the blood to the bones. Before you receive Prolia, tell your doctor if you have kidney disease (or if you are on dialysis), a weak immune system, a history of hypoparathyroidism or thyroid surgery, a history of intestinal surgery, a condition that makes it hard for your body to absorb nutrients from food, or if you are allergic to latex. An allergic reaction is possible after using Prolia. They need to know if you have any of these conditions: This medicine is for injection under the skin. Do not stop using this medicine without first talking to your doctor. Youll likely receive Prolia long term if you and your doctor decide that the drug is effective and safe for you. Theyll do this with certain tests, such as a bone scan or ultrasound. Sciatica is described as a shooting pain that travels from the lower back down a leg. It blocks the effects of certain bone cells called osteoclasts in breaking down bone tissue. And some of these side effects are more common with certain uses of Prolia. Your doctor can discuss with you how to manage side effects and whether youll need to stop taking Prolia due to side effects. This drug may not be the right treatment for your condition if you have certain medical conditions or other factors that affect your health. And you should continue using birth control for at least 5 months after stopping Prolia. * Sex and gender exist on spectrums. But, in some cases, alcohol can affect your balance and increase your risk for falls. Prolia is a monoclonal antibody. for breast cancer that has not spread to other parts of the body. in your skin, lower stomach area (abdomen), bladder, or ear may happen. Call your doctor right away if you have signs of infection such as: swelling, pain, tenderness, warmth, or redness anywhere on your body; pain and burning when you urinate, painful urination; bladder infection (painful or difficult urination); lung infection (cough, shortness of breath); cold symptoms such as stuffy nose, sneezing, sore throat; This is not a complete list of side effects and others may occur. To learn about other mild side effects, talk with your doctor or pharmacist, or read Prolias medication guide. If youre pregnant or breastfeeding, or considering either, talk with your doctor. If you have questions about treatment options for osteopenia or arthritis, talk with your doctor. If you develop high cholesterol with Prolia, your doctor can guide you on which treatment options are right for your condition. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. (Vitamin D helps your body absorb calcium.) Prolia also carries a warning about hypocalcemia, which is a low level of Theres no information available to know whether Prolia is passed into breast milk or if its safe to take while breastfeeding. Prolia should not be used during pregnancy. But its not clear how often this side effect occurred in clinical trials. Instead, it belongs to a different group of medications called biologics. Continue reading, Prolia (denosumab) has not been associated with weight gain in clinical studies. for prostate cancer that has not spread to other parts of the body. If youd like more information about Prolia use during pregnancy or while breastfeeding, talk with your doctor. If you have serious side effects from Prolia, call your doctor right away. DENOSUMAB (den oh sue mab) slows bone breakdown. Do not use denosumab if you are pregnant. See what this means for you in the chart below. These side effects include: Your risk for these serious side effects may be higher if youre older and have certain dental procedures. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem. Serious side effects that have been reported and their symptoms include: * To learn more, see Does Prolia cause long-term side effects? in the FAQs about the side effects of Prolia section below. Prolia and Forteo are both used to treat osteoporosis. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed. Our phase IV clinical studies alone cannot establish cause-effect relationship. The drug may also be used off-label for osteopenia, but usually, you dont need medications for osteopenia. (A placebo is a treatment with no active drug.). Xgeva is another brand of denosumab that treats high calcium levels caused by cancer and prevents bone breaks. Learn strategies you can use today. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Other drugs may interact with denosumab, including prescription and over-the-counter medicines, vitamins, and herbal products. (With off-label use, a drug is used to treat conditions other than those its been approved to treat.). Yoga is an excellent way to manage symptoms of osteoporosis. Talk to your health care professional or pharmacist for more information. Fracture in the spine after stopping Prolia treatment. It is important to check supplement labels to ensure that the product meets United States Pharmacopeia (USP) standards. Your doctor can help you decide which drug is better for your needs. Tell your doctor if youd like to know more about these drugs. Vertigo (dizziness) was reported in some people who received Prolia for osteoporosis, but this was a less common side effect. (such as prednisone) for at least six months and are at high risk for fracture. Talk with your doctor about the risks of using this drug during pregnancy. To help prevent low calcium, your healthcare provider may also For Xgeva, talk to your pediatrician regarding the use of this medicine in children. If youve been diagnosed with osteoporosis, your doctor may discuss Prolia with you. With osteopenia, your bone mineral density (BMD) is lower than usual. Prolia is usually given once every 6 months. Your low blood calcium must be treated before you receive Prolia. Over time, Prolia helps to improve the density and strength of your bones by slowing bone loss. Web You will receive Prolia 1 time every 6 months. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Prolia comes with a warning about a low level of calcium in the blood. Based on your dental history, your doctor can discuss with you the risks of using Prolia. Other side effects may continue for as long as you receive the medication, but they can often be relieved with other treatments. This makes your bones weak and increases your risk for bone fractures or breaks. Learn more about some of the side effects Prolia may cause. For instance: Both Prolia and Forteo are given as injections under your skin. But if you think youre having a medical emergency, call 911 or your local emergency number. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. Talk with your doctor about the best options for treating your condition. It may also be higher if you have dental work done while youre taking Prolia. Some people may have dental or jaw-related issues with Prolia use. With arthritis, you have pain and inflammation of your joints. In addition, you should use effective birth control while youre taking Prolia. Over time, Prolia can reduce bone loss and make your bones stronger. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. (A low blood calcium level is a possible side effect of Prolia.). They can help answer any questions you have about side effects from taking the drug. You may wonder how Prolia compares with the alternative drug Reclast. Before you start Prolia treatment, your doctor will examine the inside of your mouth. Instead, your doctor may recommend that you make certain changes to your diet, such as increasing your calcium and vitamin D intake. A solid routine can help to strengthen your muscles and bones, which helps to lower your, If you have osteoporosis, diet plays a vital role in managing your condition. Be sure to talk with your doctor about which medication is right for you. What's the difference between Prolia and Reclast? If they find any cavities or infection, theyll typically delay having you receive Prolia until your dental problems are treated. Talk with your doctor about your health history and discuss your risks with Prolia treatment. This medicine may cause jaw bone problems (osteonecrosis). The fractures may require surgeries, take several months to heal, or both. Store in the original container away from heat and light. may occur. Osteoporosis Is Common in Older Men, Know the Risks, Your Guide to Osteoporosis and Broken Bones: Know Your Risks, 7 Things You Can Do Today to Prevent Osteoporosis, treat osteoporosis in males* and in females* whove gone through, treat osteoporosis caused by long-term use of, increase bone mass in females using certain, increase bone mass in males using certain treatments for, increased risk of bone fracture after stopping Prolia treatment, such as having multiple, severe pain in your joints, bones, and muscles, skin-related side effects, such as rash, dry skin, or blisters, decreased bone production, which means your bones take longer to make new bone tissue, dental problems and jaw-related side effects*, jaw necrosis (death of tissue in the jawbone), Prolias active ingredient is denosumab. For a basic overview of Prolia, including details about its uses, see this article. To prevent osteoporotic fractures, combined calcium and vitamin D supplementation is recommended at the correct dosage (1,0001,200 mg calcium and 800 IU of vitamin D per day). Supplementation should be targeted on vulnerable groups such as elderly and institutionalised people, patients with osteoporosis and individuals on glucocorticoids. Numerous trials have shown that calcium and vitamin D supplementation is effective and safe. In particular, no increased cardiovascular risk was observed. Motion sickness, nausea, and vomiting can occur as a part of vertigo. To learn more about these two drugs, check out this drug article. But tingling may be a symptom of side effects such as sciatica and hypocalcemia. Bone density decreases with time, and some people have a risk of developing weak or brittle bones. American Dental Association (ADA) recommendations say that tooth extractions are allowable if needed during Prolia treatment, if both you and your dentist agree. You might like to know how Prolia and the drug Evenity compare. Follow your doctor's instructions. You can often relieve mild pain in your back or bones with an over-the-counter (OTC) pain medication. Before you have any dental work done, tell your dentist you are receiving this medicine. They can also happen if you have certain conditions or if you take certain medications. Whats the Connection Between Estrogen and Osteoporosis? Certain side effects of Prolia that may last longer than others include: Ask your doctor about serious or long-lasting side effects of Prolia and what you should know before starting this drug. Common interactions include nausea among females and fatigue among males. Use of the term female in this article refers to sex assigned at birth. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. These supplements help to prevent a low calcium level while youre taking Prolia. In rare cases, your doctor may have you self-inject Prolia at home. The risk is real, but rare. If youre concerned about side effects with Prolia, talk with your doctor. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.).
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